Answer by dotnetspec for KeePass: use a key file or a regular password?

For a newbie to password management:
Password only
Why?
It cuts your file (mis)management concerns in half and limits it to just one file.
A KeepassX .kdbx db can be secured with a mixed 64 character password. That's plenty of scope to create a long, secure password.
This helps to underline that the (strong) password (in your head) is your primary focus (not where you kept the keyfile etc.).
If you have trouble remembering passwords (of course, we all do) use a password manager (like KeepassX) and you'll only have to remember one good strong one.